Research in the Bothner lab has two main focuses: (1) understanding the assembly, cell entry, and infection process of icosahedral viruses; (2) use of chemical and systems biology to study cellular response to stress. This research takes us from the atomic scale provided by high resolution structural models of virus capsids to complex interaction networks of nucleic acids, proteins, and metabolites that make up a living system. This seminar will focus on our efforts to elucidate the functional implications of protein dynamics in Hepatitis B (HBV) and Adeno associated viruses (AAV). HBV is a major health concern world wide, whereas AAV is licensed for use as a gene therapy delivery vehicle.
Prof. M.G. Finn (404-385-0906)