Prof. Sherry Chemler

3201A MoS&E
Thursday, February 20, 2014 - 11:00am to 12:00pm

Leveraging the Dual Polar/Radical Reactivity in Copper(II)-Catalyzed Alkene Difunctionalization Reactions; Applications in Heterocycle Synthesis

Alkenes are readily accessible prochiral functional groups.  Metal-catalyzed alkene difunctionalization can enable efficient and stereoselective synthesis of vicinal diamines, amino alcohols and ethers, among others. The enantioselective copper(II)-catalyzed aminooxygenation, diamination and carboetherification of alkenes for the synthesis of chiral nitrogen and oxygen containing heterocycles such as indolines, pyrrolidines and tetrahydrofurans, will be presented.  These reactions benefit from the polar properties of copper(II), a Lewis acid capable of coordinating tightly both substrates and chiral ligands, as well as its radical character, which can enable powerful organic radical reactions to occur.

Contact Information: 

Prof. Stefan France (404-385-1796)

Map of Georgia Tech

School of Chemistry & Biochemistry

901 Atlantic Drive Atlanta, GA 30332-0400

(404) 894-4002 (phone) | (404) 894-7452 (fax)