Lawrence A. Bottomley Professor Office: L1-238 ES&T Phone: 404-894-4014 Fax: 404-894-7452 E-mail Lawrence A. Bottomley Research Group Web site

B.S., 1976, California State University; Ph.D., 1980, University of Houston

Research Interests

Bottomley's research interests are in biological applications of scanning probe microscopy, microcantilever and microacoustic array sensors, and electroanalytical chemistry. Current projects include:

• Force Spectroscopy of Biopolymers: Correlating Molecular Structure with Single Molecule Elasticity
• Microcantilever and Microacoustic Array-based Immunoassays
• Chemical Force Microscopy on Single-walled Carbon Nanotubes
• Atomic Force Microscopic Imaging Drug-DNA Complexes
• Reductive Biotransformation and Decolorization of Reactive Anthraquinone and Phthalocyanine Dyes
• Theory and Application of Cyclic Square Wave Voltammetry

Recent Publications

"Cationic Polyacrylamide Conformation on Mica Studied by Single Molecule "Pulling" with Scanning Probe Microscopy," Brotherson, Brett; Bottomley, Lawrence A.; Ludovice, Peter; Deng, Yulin, Macromolecules, 2007, 40(13), 4561-4567.

“Reaction kinetics and mechanism of zero-valent iron reductive transformation of the anthraquinone dye reactive blue 4.” W. J. Epolito, L. A. Bottomley, and S. G. Pavlostathis, Environmental Chemistry Preprints, 2006, 46(1), 1041-1046.

“Electrooxidative decolorization of reactive textile dyes.” R. D. Ko, O. Braide, J. F. Parker, L. A. Bottomley, and S. G. Pavlostathis, Environmental Chemistry Preprints, 2006, 46(1), 55-59.

"Injection-moulded scanning force microscopy probes," A. W. McFarland, M. A. Poggi, L. A. Bottomley, J. S. Colton, Nanotech., 2005, 16, 1249-1252.

"Characterization of microcantilevers solely by frequency response acquisition," A. W. McFarland, M. A. Poggi, L. A. Bottomley, J. S. Colton, J. Micromech. Microengrg., 2005, 15, 785-791.

"Injection moulding of high aspect ratio micron-scale thickness polymeric microcantilevers," A. W. McFarland, M. A. Poggi, L. A. Bottomley, J. S. Colton, Nanotech., 2004, 15, 1628-1632.

"Correlation of morphology and device performance in inorganic-organic TiO2-polythiophene hybrid solid-state solar cells," L. B. Roberson, M. A. Poggi, J. Kowalik, G. P. Smestad, L. A. Bottomley, L. M. Tolbert, Coord. Chem. Rev., 2004, 248, 1491-1499.

"An improved method for calculating the spring constant of AFM cantilevers with a nonrectangular cross-section," M. A. Poggi, A. W. McFarland, J. S. Colton, L. A. Bottomley, Anal. Chem., 2004, 76, ASAP article.

"Polymeric microcantilevers for sensing applications," L. A. Bottomley, A. W. McFarland, M. A. Poggi, J. S. Colton, Polymeric Mater. Sci. Engrg., 2004, 90, 164-165.

"Force spectroscopy of single walled carbon nanotubes for improved polymer composites," L. A. Bottomley, M. A. Poggi, A. W. McFarland, J. S. Colton, P. T. Lillehei, Polymeric Mater. Sci. Engrg., 2004, 90, 149-151.

"Force spectroscopy of elastin mimetic polypeptides," L. A. Bottomley, J. Anderson, V. P. Conticello, Polymeric Mater. Sci. Engrg ., 2003, 88, 271-272.

"Measuring the compression of a carbon nanospring," M. A. Poggi, J. S. Boyles, L. A. Bottomley, A. W. McFarland, J. S. Colton, C. V. Nguyen, R. M. Stevens, P. T. Lillehei, Nano Letts., 2004, 4, 1009-1016.

"Scanning probe microscopy," M. A. Poggi, E. D. Gadsby, L. A. Bottomley, W. P. King, E. Oroudjev, H. G. Hansma, Anal. Chem., 2004, 76, 3432-3446.

"Plastic tip arrays for force spectroscopy," P. T. Lillehei, M. A. Poggi, B. J. Polk, J. A. Smith, L. A. Bottomley, Anal. Chem., 2004, 76, 3861-3863.

"Plastic bio-MEMS sensors," A. W. McFarland, J. S. Colton, M. A. Poggi, L. A. Bottomley, ANTEC Proc., 2004, Chicago IL, 3717-3721.

"Impact of nano- and mesoscale particles on the performance of microcantilever-based sensors," L. A. Bottomley, M. A. Poggi, S. Shen, Anal. Chem., 2004, ASAP article.

"Production and characterization of polymer microcantilevers," Andrew W. McFarland, M. A. Poggi, .L. A. Bottomley, J. S. Colton, Review of Scientific Instruments, 2004, 75(8), 2756-2758.

"Measuring the adheasion forces between alkanethiol-modified AFM cantilevers and single walled carbon nanotubes," M. A. Poggi, L. A. Bottomley, Nano Letts., 2004, 4, 61-64.

"Temperature-dependence of water bridge formation in atomic force microscopy," B. A. Nelson, L. A. Bottomley, M. A. Poggi, W. P. King, Proc. IMECE '03, 2003 ASME International Mechanical Engineering Congress, Washington DC, Nov. 2003.

"Chemical force microscopy of single walled carbon nanotubes," Lawrence A. Bottomley, Mark A. Poggi, Peter T. Lillehei, Proc. Electrochem. Soc., 2003, Fullerenes 13, 297-304.

"Microcantilever sensing of particles in liquid streams: Thin-film coating impacts sensor performance," S. Shen and L. A. Bottomley, in the ACS Symposium Series entitled Characterization of Thin Films, M. Soriaga, J. L. Stickney, L. A. Bottomley, and Y.-G. Kim, Eds., 2002, 349-359.

"Scanning probe microscopy," M. A. Poggi, L. A. Bottomley and P. T. Lillehei, Anal. Chem., 2002, 74, 2851-2862.

"Scanning force microscopy of nucleic acid complexes," P. T. Lillehei and L. A. Bottomley, in Drug-Nucleic Acid Interactions, J. B. Chaires and M. J. Waring, Eds., Methods in Enzymology, 2001, 340, 234-251.