Office: MS&E 2100K
B. S., Duke University, 2000; Ph. D., Johns Hopkins University, 2005; Postdoctoral Associate, Emory University, 2005-2007
FACES Career Initiation Grant, 2007; NIH Postdoctoral Research Supplement to Promote Diversity, 2005; Ford Foundation Dissertation Fellowhip, 2004; National Organization for the Professional Advancement of Black Chemists and Chemical Engineers (NOBCChE)/GlaxoSmithKline Lendon Pridgen Fellowship, 2004; Chambers Fellowship (Johns Hopkins University), 2004; United Negro College Fund/Merck Science Initiative Dissertation Fellowship, 2002; Pfizer Diversity Fellowship, 2002
Our research plan spans the realm of synthetic organic chemistry, medicinal chemistry, natural products chemistry and asymmetric catalysis. Our research is motivated by the interest in developing new synthetic methodologies that can be applied toward the construction of complex natural products and pharmaceutically-interesting compounds.
Our current research interests include (but are not limited to):
Method Development. Our group is interested in the design of efficient methodologies to accomplish the formation of carbon-carbon and carbon-heteroatom bonds with the intent to apply the methodology toward the synthesis of complex natural and unnatural targets.
Natural Product Synthesis. Approaches to natural products not only inspire the development of new synthetic strategies, but often unveil unexpected and often interesting reactivity. Targets are chosen for their interesting biological activity along with their sheer complexity. We are interested in exploring both modular and convergent approaches to complex targets that enable facile derivatization for the development of combinatorial libraries.
Medicinal Chemistry. Medicinal or pharmaceutical chemistry lies at the intersection of chemistry and pharmacy. Our group is interested in the design, synthesis and development of pharmaceutical drugs, or other chemical entities suitable for therapeutic use. We are further interested in the study of their biological properties and their quantitative structure-activity relationships (QSAR). Given that medicinal chemistry is a highly interdisciplinary science, we aim to establish several collaborations with biologists, biochemists, and computational chemists to facilitate the design and development process. In particular, we aim to develop therapeutics toward the treatment of various forms of cancer, HIV, diabetes, and neurological disorders, such as Alzheimer's and Parkinson's disease.
D. V. Patil, M. A. Cavitt, S. France. "An Efficient Synthesis of Hydropyrido[1,2-a]indole-6(7H)-ones via Indium-Catalyzed Homo-Nazarov Cyclizations" Submitted for publication.
L. H. Phun, D. V. Patil, M. A. Cavitt, S. France. "A Catalytic Homo-Nazarov Cyclization Protocol for the Synthesis of Heteroaromatic Ring-Fused Cyclohexanones" Organic Letters 2011, 13, 1952-1955.
D. V. Patil, L. H. Phun, S. France. "Indium-Catalyzed Homo-Nazarov Cyclizations of Alkenyl Cyclopropyl Ketones" Organic Letters 2010, 12, 5684-5687.
X. Liu, C.-B. Chan, S. Pradoldej, S.-W. Jang, L. H. Phun, S. France, G. Xiao, Y. Jia, H. R. Luo, K. Ye. "A Synthetic 7,8-Dihydroxyflavone Derivative Promotes Neurogenesis and Exhibits Potent Antidepressant Effect" Journal of Medicinal Chemistry 2010, 53, 8274-8286.
S.-W. Jang, X. Liu, C.-B. Chan, S. A. France, I. Sayeed, D. Stein, W. Tang, X. Lin, G. Xiao, R. Andero, Q. Chang, K. J. Ressler, K. Ye. "Deoxygedunin, a natural product with potent neurotrophic activity in mice" PLoS One 2010, 5, e11528.
S. France, L. H. Phun. "Enantio- and diastereoselective Rh(II)-catalyzed 1,3-dipolar cycloadditions of carbonyl ylides and their recent applications in complex molecule synthesis" Current Organic Synthesis 2010, 7, 332-347.