Boris Mizaikoff Associate Professor Office: ES&T L-1240 Phone: 404-894-4030 Fax: 404-894-7452 E-mail Boris Mizaikoff Research Group Web site

B.S., Vienna University of Technology; Ph.D., Vienna University of Technology; Postdoctoral, University of Texas at Austin

Research Interests

Infrared Optical Sensor Systems. Mid-infrared optical sensor systems, operating in the spectral window from 2-20 5m, are particularly attractive for optical sensing schemes since molecule specific information due to the stimulation of ground vibrational modes of organic molecules are accessible. One aim of this project is to miniaturize the light source (e.g. quantum cascade lasers), the waveguide (e.g. integrated planar structures or hollow waveguides) and the detector (e.g. quantum well devices) in order to develop possibly integrated devices for qualitative and quantitative determination of organic compounds in the liquid phase and in the gas phase. A second focus is to monitor methane and hydrocarbon in seawater by developing a reliable and rugged sensing system, which is suitable for in-situ measurements.

Scanning Electrochemical Microscopy (SECM) for the Characterization and Optimization of Chemical Recognition Interfaces. Scanning electrochemical microscopy (SECM) provides complementary information by simultaneously recording topographical and electrochemical information with a lateral resolution in the sub-micrometer range. SECM is suitable for the non-destructive investigation of the activity of biological systems, and characterization of biomimetic surfaces. Current research is focused on new mechanisms to separate the electrochemical from the topographical information by integrating the features of SECM and other microscopies, such as AFM.

Molecularly Imprinted Polymers. Molecularly imprinted polymers (MIPs) are functionalized polymers that can "recognize" guest molecules because the shape and functionality of the guest has been "imprinted" during the polymerization. Having great promise for chemical sensing, separation techniques, and artificial receptor-based assays, such systems are being designed, synthesized, and examined by single-molecule and other spectroscopies.

Recent Publications

"AFM-tip-integrated amperometric microbiosensors: High-resolution imaging of membrane transport," A. Kueng, C. Kranz, A. Lugstein, E. Bertagnolli, B. Mizaikoff, Angew. Chemie-Int. Ed., 2005, 44 (22), 3419-3422.

"Advances in the analysis of mycotoxins and its quality assurance," R. Krska, E. Welzig, F. Berthiller, A. Molinelli, B. Mizaikoff, Food Addit. Contam., 2005, 22 (4): 345-353.

"Molecularly imprinted polymers-potential and challenges in analytical chemistry," J. O. Mahony, K. Nolan, M. R. Smyth, B. Mizaikoff, Anal. Chimica Acta, 2005, 534 (1), 31-39.

"Towards the rational development of molecularly imprinted polymers: H-1 NMR studies on hydrophobicity and ion-pair interactions as driving forces for selectivity," J. O'Mahony, A. Molinelli, K. Nolan, M. R. Smyth, B. Mizaikoff, Biosen. Bioelectron., 2005, 20 (9): 1884-1893.

"Numerical simulation of scanning electrochemical Microscopy experiments with frame-shaped integrated atomic force microscopy-SECM probes using the boundary element method," O. Sklyar, A. Kueng, C. Kranz, B. Mizaikoff, A. Lugstein, E. Bertagnolli, G. Wittstock, Anal. Chem., 2005, 77 (3): 764-771.

"Analysis of corrosion processes at DLC protected ZnSe waveguide surfaces," M. Janotta, D. Rudolph, A. Kueng, C. Kranz, H.-S. Voraberger, W. Waldhauser, B. Mizaikoff, Langmuir, 2004, 20, 8634-8640.

"Mapping of enzyme activity of detection of enzymatic products during AFM imaging with integrated SECM-AFM probes," C. Kranz, A. Kueng, A. Lugstein, E. Bertagnolli, B. Mizaikoff, Ultramicroscopy, 2004, 100, 127-134.

"Chemometric correction of drift effects in optical spectra," F. Vogt, H. Steiner, K. Booksh, B. Mizaikoff, Appl. Spectrosc., 2004, 58, 683-692.

"Scanning electrochemical microscopy imaging of rhodocrosite dissolution using gold amalgam electrodes," D. Rudolph, C. Kranz, S. Neuhuber, M. Taillefert, B. Mizaikoff, Analyst, 2004, 129, 443-448.

"Fault tolerant spectroscopic data evaluation based on extended principal component regression correcting for spectral drifts and uncalibrated spectral features," F. Vogt, B. Mizaikoff, J. Chemometrics, 2004, 17, 660-665.

"Simultaneous quantitative determination of benzene, toluene and xylenes in water with mid-infrared evanescent field spectroscopy," M. Karlowatz, M. Kraft, B. Mizaikoff, Anal. Chem., 2004, 76, 2643-2648.

"Direct analysis of oxidizing agents in aqueous solution with attenuated total reflectance mid-infrared spectroscopy and diamond-like carbon protected waveguides," M. Janotta, F. Vogt, Hannes-Stefan Voraberger, W. Waldhauser, J. M. Lackner, C. Stotter, M. Beutl, B. Mizaikoff, Anal. Chem., 2004, 76, 384-391.

"Amperometric ATP biosensor based on polymer entrapped enzymes," A. Kueng, C. Kranz, B. Mizaikoff, Biosen. Bioelectron., 2004, web released.

"Combination of sorption tube sampling and thermal desorption with hollow waveguide FT-IR spectroscopy for atmospheric trace gas analysis: Determination of atmospheric ethene at the lower ppb level," O. A. Pogodina, V. V. Pustogov, F. de Melas, C. Haberhauer-Troyer, E. Rosenberg, H. Puxbaum, A. Inberg, N. Croitoru, B. Mizaikoff, Anal. Chem., 2004, 76, 464-468.

"Scanning probe microscopy with integrated biosensors," A. Kueng, C. Kranz, B. Mizaikoff, Sensor Letts., 2003, 1, 2-15.

"Hollow-waveguide gas sensing with room-temperature quantum cascade lasers," C. Charlton, F. de Melas, A. Inberg, N. Croitoru, B. Mizaikoff, IEE Proc.-Optoelectron., 2003, 150, 306-309.

"Sol-gel based mid-infrared evanescent wave sensors for detection of organophosphate pesticides in aqueous solution," Markus Janotta, Manfred Karlowatz, Frank Vogt Boris Mizaikoff, Analy. Chim. Acta, 2003, 496, 339-348.

"Dynamic determination of the dimension of PCA calibration models using F-statistics," F. Vogt, B. Mizaikoff, J. Chemometrics, 2003, 17, 346-357.

"Combination of a mid-infrared hollow waveguide gas sensor with a supported capillary membrane sampler for the detection of organic compounds in water," F. de Melas, V. V. Pustogov, D. K. Wolcott, D. C. Olson, A. Inberg, N. Croitoru, B. Mizaikoff, Intern. J. Environ. Anal. Chem., 2003, 83, 573-583.

"Integrated AFM-SECM in tapping mode: Simultaneous topographical and electrochemical imaging of enzyme activity," A. Kueng, C. Kranz, A. Lugstein, E. Bertagnolli, B. Mizaikoff, Angew. Chem. Int. Ed., 2003, 42, 3238-3240.

"Simultane topographische und elektrochemische Abbildung von EnzymaktivitŠt mit integrierten AFM-SECM-Rasternahfeldsonden im AFM-Tapping modes," A. Kueng, C. Kranz, A. Lugstein, E. Bertagnolli, B. Mizaikoff, Angew. Chem., 2003, 115, 3558-3360.

"Sol-gel-coated mid-infrared fiber-optic sensors," M. Janotta, A. Katzir, B. Mizaikoff, Appl. Spectrosc., 2003, 57, 823-828.

"New frontiers for mid-infrared sensors: Towards deep sea monitoring with a submarine FT-IR sensor system," M. Kraft, M. Jakusch, M. Karlowatz, A. Katzir, B. Mizaikoff, Appl. Spec., 2003, 57, 591-599.

"Mid-IR fiber-optic sensors," B. Mizaikoff, Anal. Chem., 2003, 75, 258A-267A.

"Development and optimization of a mid-infrared hollow waveguide gas sensor combined with a supported capillary membrane sampler," F. de Melas, V. V. Pustogov, N. Croitoru, B. Mizaikoff, Appl. Spec., 2003, 57, 600-606.

"In situ sensing of volatile organic compounds in groundwater: First field tests of a mid-infrared fiber-optic sensing system," H. Steiner, M. Jakusch, M. Kraft, M. Karlowatz, T. Baumann, R. Niessner, W. Konz, A. Brandenburg, K. Michel, C. Boussard-PlŽdel, B. Bureau, J. Lucas, Y. Reichlin, A. Katzir, N. Fleischmann, K. Staubmann, R. Allabashi, J. M. Bayona, B. Mizaikoff, Appl. Spec., 2003, 57, 607-613.

"Application of mid-infrared spectroscopy: Measuring hydrogen peroxide concentrations in bleaching baths," H. Voragerger, V. Ribitsch, M. Janotta, B. Mizaikoff, Appl. Spec., 2003, 57, 574-579.

"Improving methods of analysis for mycotoxins: Molecularly imprinted polymers for deoxynivalenol and zearalenone," R. Weiss, M. Freudenschuss, R. Krska, B. Mizaikoff, Food Additives and Contaminants, 2003, 20, 386-395.

"Mini spectrometer with silver halide sensor fiber for in situ detection of chlorinated hydrocarbons," T. Beyer, P. Hahn, S. Hartwig, W. Konz, S. Scharring, A. Katzir, H. Steiner, M. Jakusch, M. Kraft. B. Mizaikoff, Sensors and Actuators B, 2003, 90, 319-323.

"Secured PCR (sPCR) for detection and correction of PCR calibration model failures induced by uncalibrated spectral features," F. Vogt, B. Mizaikoff, J. Chemometrics, 2003, 17, 225-236.

"Online sensing of volatile organic compunds in groundwater using mid-infrared fibre optic evanescent wave spectroscopy: A pilot scale test," H. Steiner, K. Staubmann, R. Allabashi, N. Fleischman, A. Katzir, Y. Reichline, B. Mizaikoff, Water Science and Technology, 2003, 47, 121-126.

"The automated sample preparation system MixMaster for investigation of volatile organic compounds with mid-infrared evanescent wave spectroscopy," F. Vogt, M. Karlowatz, M. Jakusch, B. Mizaikoff, The Analyst, 2003, 128, 397-403.

"Mini spectrometer with silver halide sensor fiber for in situ detection of chlorinated hydrocarbons," T. Beyer, P. Hahn, S. Hartwig, W. Konz, S. Scharring, A. Katzir, H. Steiner, M. Jakusch, M. Kraft, B. Mizaikoff, Sens. Actuators B, 2002, 90, 319-323.

"Model-based optimal design of polymer-coated chemical sensors," C. Phillips, M. Jakusch, H. Steiner, B. Mizaikoff, A. G. Federov, Anal. Chem., 2003, 75, 1106-1115.

"Infrared optical sensors for water quality monitoring," B. Mizaikoff, Water Sci. & Tech., 2003, 47, 35-42.

"Combined scanning electrochemical atomic force microscopy for tapping mode imaging," A. Kueng, C. Kranz, B. Mizaikoff, A. Lugstein, E. Bertagnolli, Appl. Phys. Lett., 2003, 82, 1592-1594.