Prof. Reddi and co-workers have discovered a new role for extacellular superoxide dismutase in baker's yeast,
In studies led by Claudia Montllor-Albalate, a 3rd year graduate student in the Reddi lab, it was discovered that the function of a well known antioxidant enzyme, Cu/Zn Superoxide Dismutase (SOD1), is in fact largely dispensable for its role in combating oxidative stress. Rather, Montllor-Albalate discovered that the vast majority of SOD1 may be more important in the redox contol of cell metabolism and signaling. Her discovery completely changes how we think about SOD1 biology and has implications in the treatment of a variety of diseases, from Lou Gehrig's disease to certain cancers.
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