Dr. Jevgenij Raskatov

MoSE 3201A
Monday, December 16, 2013 - 4:00pm to 5:00pm

Py-Im Polyamides – from DNA Recognition to In Vivo Experiments

Pyrrole-imidazole (Py-Im) polyamides represent a class of modular DNA minor groove binders with affinity and specificity comparable to the values observed with typical DNA binding proteins. These cell-permeable molecules have been shown to affect transcriptional responses in cell culture and, more recently, in vivo. Antitumor activity has been demonstrated in a  subcutaneous xenograft model of prostate cancer.

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Prof. Wendy Kelly (404-385-1154)

Map of Georgia Tech

School of Chemistry & Biochemistry

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