Over the past several years we have been developing substitution reactions of unsaturated alcohols. Nucleophilic substitution is an example of perhaps the most basic complexity building transformation available to the synthetic organic chemist. Our work addresses the issue of using an unactivated hydroxyl leaving group to produce water as the only byproduct. This lecture will cover recent developments from my laboratory aimed at developing new catalytic transformations that began with a proposed Claisen rearrangement and took us to condensation reactions and eventually the development of ligands for enantioselective catalysis.
Prof. Stefan France (404-385-1796).