Our lab is engineering synthetic membranes through artificial phospholipid synthesis and modification. Living organisms carry out de novo synthesis and subsequent remodeling of phospholipid membranes. The development of comparatively dynamic artificial lipid membranes will require simple methods to mimic how native phospholipid membranes are synthesized and remodeled. Using reversible coupling reactions, we have been able to sequentially form and remodel artificial lipid membranes. Interestingly, in situ remodeling of phospholipids is capable of controlling micrometer scale changes in vesicle spatial organization, composition, and morphology.
M.G. Finn (email@example.com)