Alkenes are readily accessible prochiral functional groups. Metal-catalyzed alkene difunctionalization can enable efficient and stereoselective synthesis of vicinal diamines, amino alcohols and ethers, among others. The enantioselective copper(II)-catalyzed aminooxygenation, diamination and carboetherification of alkenes for the synthesis of chiral nitrogen and oxygen containing heterocycles such as indolines, pyrrolidines and tetrahydrofurans, will be presented. These reactions benefit from the polar properties of copper(II), a Lewis acid capable of coordinating tightly both substrates and chiral ligands, as well as its radical character, which can enable powerful organic radical reactions to occur.
Prof. Stefan France (404-385-1796)