Fall 2015 Safety Awards Announced!

Cynthia Martin, Dylan Christiansen and Johanna Smeekens receive the VWR Safety award for their remarkable efforts to keep GT-CHEM safe!

Glass shop featured in "Hidden Georgia Tech"

Across the Georgia Tech campus, hidden spaces and forgotten places await rediscovery.

Graduate Student Raynold Shenje Gains Valuable Industry Experience

France Group graduate student starts a one-year internship at GlaxoSmithKline’s research laboratories.

Georgia Tech announces a new graduate program in quantitative biosciences

The Quantitative Biosciences Graduate Program (QBioS) is now accepting applications from students who want to enter a rapidly emerging field working at the leading edge of research that spans biological scales from molecules to organisms to ecosystems.

Georgia Tech among institutions part of the Center for Sustainable Nanotechnology

Prof. Rigoberto Hernandez is part of the $20 million NSF research center focusing on the molecular mechanisms by which nanoparticles interact with biological systems

Prof. Jean-Luc Bredas Wins the ACS Award for Chemistry of Materials

A top ACS honor in materials chemistry goes to a Georgia Tech professor.

Perry Group Develops a New Capacitor Dielectric Material

Professor Perry describes this new research, "Sol-gels with organic groups are well known and fatty acids such as phosphonic acids are well known, but to the best of our knowledge, this is the first time these two types of materials have been combined into high-density energy storage devices."

GT Homecoming

Don't miss your chance to see one of the biggest games of the season, GT vs. FSU, at this year's Homecoming & Reunion Weekend. Registration is now open! Join classmates and bring your family October 22-24 for a weekend of Yellow Jacket pride.

Doctoral Candidate Daisy Bourassa Receives AAUW American Fellowship

The American Association of University Women (AAUW) awarded a 2015–16 American Fellowship to Daisy Bourassa.

Xia group publishes a new method in Science

Xia and co-workers demonstrated the fabrication of platinum nanocages with walls as thin as a few atomic layers (or below one nanometer), together with a well-defined, controllable surface structure. These nanocages exhibited greatly enhanced catalytic activity and durability toward oxygen reduction, a key reaction in the fuel cell technology.

Seminars & Events

Prof. Ken Jordan - University of Pittsburgh
Physical Division Seminar - Friday, October 9, 2015 - 4:00pm - MoSE 3201A
Prof. Kenneth Merz - University of Michigan
Colloquium - Thursday, October 15, 2015 - 4:00pm - MoSE G011
Prof. Kenneth Merz - Student Seminar - University of Michigan
Special Seminar - Friday, October 16, 2015 - 11:00am - MoSE 3201A
Meeting - Tuesday, October 20, 2015 - 11:00am - MoSE 3201A

Featured Research

Article Title
Research Authors
Arren Z. Washington, Subhasish Tapadar, Alex George, Adegboyega K. Oyelere.
Bioorganic and Medicinal Chemistry (2015), Vol. 23(16), 5198-5209
Miscellaneous Details
This work was financially supported in part by NASA Astrobiology Institute [NNA09DA78A] and by NIH RO1 Grant R01CA131217 (A.K.O.). A.Z.W. is a thankful recipient of the GAANN predoctoral fellowship from the Georgia Tech School of Chemistry and Biochemistr

The ribosome is the primary protein synthesis machine in the cell and is a target for treatment of a variety of diseases including bacterial infection and cancer. The ribosomal peptide exit tunnel, the route of egress for the nascent peptide, is an inviting site for drug design. Toward a rational engagement of the nascent peptide components for the design of small molecule inhibitors of ribosome function, we designed and disclosed herein a set of N-10 indole functionalized azithromycin analogs. The indole moiety of these compounds is designed to mimic the translation stalling interaction of SecM W155 side-chain with the prokaryotic (Escherichia coli) ribosome A751 residue. Many of these N-10 functionalized compounds have enhanced translation inhibition activities against E. coli ribosome relative to azithromycin while a subset inhibited the growth of representative susceptible bacteria strains to about the same extent as azithromycin. Moreover, the inclusion of bovine serum in the bacterial growth media enhanced the anti-bacterial potency of the N-10 functionalized azithromycin analogs by as high as 10-fold.

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