Mining microbial natural products for precision medicine


Natural products are drivers of remarkable phenotypic changes in the ecosystems in which they are produced, often precisely mediating multipartite transactions between organisms. As precision phenotypic drivers, natural products can be borrowed to manipulate human chemical biology, often in a therapeutically productive way. In this talk I will discuss: (1) how we can discover the next generation of precision therapies using single cell chemical biology techniques, (2) our progress towards the discovery of mediators of natural product induced antitumor immunity, and (3) the discovery of the target and mechanism of a family of natural products with promising anti-leukemic activity.